H. Steven Wiley, Ph.D.
Laboratory Fellow, WR Wiley Environmental Molecular Sciences Laboratory, Chief Scientist for Scientific ProgramsResearch Interests
Dr. Wiley's research interests have focused on understanding mechanisms of cell communication using the epidermal growth factor receptor (EGFR) system as a model. He pioneered methods for the quantitative analysis of receptor dynamics in mammalian cells and published some of the first computer models of receptor regulation. He has been a major contributor to the field of receptor research, particularly with regard to the control of receptor distribution within cells. More recently, his work has focused on understanding the regulation of autocrine signaling in epithelial cells from a systems biology perspective to understand its role in tissue homeostasis. He is also interested in understanding how networks of interacting proteins are regulated.
Past Experience
Dr. Wiley's work is notable for combining the techniques of molecular and cellular biology with both biochemical and optical assays. The results are then used to build computer models of the underlying cellular processes. He is the author or co-author of more than 130 scientific journal articles, review articles and book chapters. He has also written 5 commercial graphics and data analysis software packages.
Education
- B.A. 1974 Biology, University of Tennessee-Knoxville
- Ph.D. 1979 Biochemistry/Cell Biology, University of Tennessee-Oak Ridge School of Biomedical Sciences
Awards, Honors, & Appointments
- Member Genomics, Computational Biology & Technology Study Section, 2006
- Elected AAAS Fellow, 2005
- R&D 100 award for designing single-chain antibody library in a yeast-display system, 2004
- Laboratory Fellow at Pacific Northwest National Laboratory, 2000
- Phi Kappa Phi Honor Society, University of Tennessee, Knoxville, 1979
- NIH Research Career Development Award, 1988-93
Publications >View All Publications
