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Photo of H. Steven Wiley

H. Steven Wiley, Ph.D.

Laboratory Fellow, WR Wiley Environmental Molecular Sciences Laboratory, Chief Scientist for Scientific Programs

P.O. Box 999, K8-93
Richland, WA 99352
Work: (509) 371-6551 Fax: () Updated: July 9, 2014

Research Interests

Dr. Wiley's research interests are focused on understanding mechanisms of cell regulatory networks using both prokaryotic and eukaryotic model systems. This work also involves mapping cellular signal transduction networks and how these networks integrate information from multiple inputs. More recently, his work has focused on the role of feedback control in signaling networks using a combination of proteomics, gene expression, biochemical and optical assays. This work requires the creation of a scalable computational infrastruc-ture for integrating multidimensional data sets as well as development of the underlying analytical technologies.

Past Experience

Dr. Wiley's work is notable for combining the techniques of molecular and cellular biology with both biochemical and optical assays. The results are then used to build computer models of the underlying cellular processes. He is the author or co-author of more than 160 scientific publications, including more than 100 articles in peer-reviewed scientific journals and 20 review articles and book chapters. He also has written several commercial graphics and data analysis software packages. Dr. Wiley has served as a reviewer for more than 30 scientific journals, is an Associate Editor of Frontiers in Genetics and is on the editorial board of The Scientist and Biophysical Journal. He also writes a monthly column for The Scientist.


  • B.A. 1974 Biology, University of Tennessee-Knoxville
  • Ph.D. 1979 Biochemistry/Cell Biology, University of Tennessee-Oak Ridge School of Biomedical Sciences

Awards, Honors, & Appointments

  • Member Genomics, Computational Biology & Technology Study Section, 2006
  • Elected AAAS Fellow, 2005
  • R&D 100 award for designing single-chain antibody library in a yeast-display system, 2004
  • Laboratory Fellow at Pacific Northwest National Laboratory, 2000
  • Phi Kappa Phi Honor Society, University of Tennessee, Knoxville, 1979
  • NIH Research Career Development Award, 1988-93

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