Office of Science

Yuehe Lin

Laboratory Fellow, Fundamental and Computational Sciences Directorate
P.O. Box 999, K4-18
Richland, WA 99352
Work: (509) 371-6241 Fax: (509) 371-6955
Updated: December 2, 2008

Dual Assignment

WR Wiley Environmental Molecular Sciences Laboratory / Interfacial & Nanoscale Science Facility

Current Activities and Projects

Dr. Yuehe Lin joined Pacific Northwest National Laboratory in 1997. Recently, he has been actively working in the nanotechnology area, particularly in the development of new nanobioelectronic devices and nanomaterials for biomedical diagnosis and drug delivery. His other research activities include developing integrated microanalytical systems for environmental and biomedical analysis, and synthesizing functional nanomaterials for biosensor development, fuel cell, and water treatment applications.

Dr. Lin is the editor of the book Handbook of Electrochemical Nanotechnology. He also serves as the North American Editor for the Journal of Nanoscience and Nanotechnology, the associate editor of the Advanced Science Letters, and Member of Editorial Advisory Board of other 15 international journals.

Dr. Lin has 13 patents (10 issued, 3 pending). Most of the patents have been licensed to industrial partners for commercialization.

Research Interests

Nanosensors; Nanobioelectronics; Lab-on-a-chip

Development of various nanosensors and nanobioelectronic devices based on nanostructured materials (e.g. nanoporous silica, carbon nanotubes, nanowires, nanoparticles, quantum dots) with enhanced sensitivity and selectivity.

Nanobioelectronics is a rapidly developing field aimed at integrating nano- and biomaterials with electronic transducers. Our interests include bioelectronic detection of proteins and nucleic acids, microfabrication, self-assembly of nanostructures, microfluidic devices (Lab-on-a-chip), nanoparticle-based bioassays, bionanomaterials, management of diabetes, point-of-care clinical testing, the development of electrochemical sensing devices for clinical and environmental monitoring, remote sensing, the development of techniques for ultratrace measurements and the design of on-line flow detectors.

Current Research Activities:

  • Nanoparticle-based bioassays.

  • Development of DNA and protein biosensors

  • Electrochemistry of nucleic acids and proteins

  • Miniaturized analytical systems and microseparation(CZE)chips

  • Application of nanomaterials for electrical assays

  • Preparation and characterization of novel nanowires

  • Nanowire biosensors and sensor arrays

  • Nanomaterial-based sensors

  • Microfabricated enzyme electrodes

  • Remote sensors for environmental monitoring and security surveillance

  • Advanced chemical and biological recognition schemes

  • Tailored (catalytic and preconcentrating) surfaces

  • Hand-held microanalyzers

  • Automated flow systems and counter-terrorist detection

  • Magneto Controlled bioelectronics

Nanostructured functional materials for separation, catalysis, and energy storage.

Synthesis of various nanostructured functional materials based on nanoporous silica, carbon nanotubes, and nanowires for separation of toxic metals, chemical conversion, and electrocatalysis (i.e. fuel cell, redox battery, hydrogen storage).

Supercritical fluid technology

Development of a variety of supercritical fluid technologies for environmental cleanup, material synthesis, chemical conversion, and thin-film coating. Our patents in supercritical fluid processing technology have been licensed to BNFL and Micron for further development into advanced processing technology for environmental cleanup and metal thin-film coatings.

Awards, Honors, & Appointments

Editorial Board:

  • Talanta

  • Journal of Biomedical Nanotechnology

  • Current Analytical Chemistry

  • International Journal of Nanotechnology

  • International Journal of Nanomedicine

  • Current Nanoscience

  • Nanomedicine

  • NanoBiotechnology

  • Current Pharmaceutical Analysis

  • Encyclopedia of Microfluidics and Nanofluidics

  • Current Chemical Biology

  • Recent Patents on Nanotechnology

  • Journal of Bionanoscience

  • The Open Biomedical Engineering Journal

  • International Journal of Electrochemical Science


  • Battelle PNNL Key Contributor Award, 2003, 2007

  • Environmental Business Journals 2007 Technology Merit Award

  • Environmental Business Journals 2001 Technology Merit Award

  • Award for Contribution and Commitment to the Environmental Health Initiative,PNNL, 2000

  • Award for Contribution and Commitment to the Biomolecular Networks Initiative,PNNL, 2001

EMSL Publications >View All EMSL Publications