Office of Science
Photo of Ljiljana Pasa Tolic

Ljiljana Pasa Tolic, Ph.D.

Capability Lead, WR Wiley Environmental Molecular Sciences Laboratory, Mass Spectroscopy

P.O. Box 999, K8-98
Richland, WA 99352
Work: (509) 371-6585 Fax: () Updated: October 18, 2011

Dual Assignment

WR Wiley Environmental Molecular Sciences Laboratory / High Performance Mass Spectroscopy Facility

Current Activities and Projects

Member of the American Chemical Society and the American Society for Mass Spectrometry (ASMS); Chair, ASMS Sanibel Committee, 2008; Member, ASMS Sanibel Committee, 2006-7; Ad-Hoc Reviewer for National Cancer Institute, NSF, and NIH; Session Chair, 18th International Symposium on MicroScale Bio-separations, 2005; Session Chair, 52nd ASMS Conference, 2004; Reviewer for Journal of Separation Science, Proteomics, Journal of Proteome Research and Analytica Chemica Acta, 2002-present; Analytical Biochemistry and Electrophoresis, 2000-present; Analytical Chemistry, Journal of the American Society for Mass Spectrometry, and Rapid Communications in Mass Spectrometry, 1995-present; Session Chair, 50th ASMS Conference, 2002.

Research Interests

Dr. Paša-Tolić’s research centers on developing sophisticated analytical methods with emphasis on Fourier transform (FT) mass spectrometry (MS) and micro- separations, as well as the application of these techniques to accurately quantify changes in protein abundance, identity and activity during cell development or in response to stimuli. Dr. Paša-Tolić’s current work responsibilities include more than 25 mass spectrometers and more than 30 commercial and custom high-performance liquid chromatography systems. Additionally, she is technical lead for the development of an exciting new capability that supports research focused on characterizing protein post-translational modifications, their coordination and dynamics.

Past Experience

Research assistant, Rudjer Bosković Institute, 1986-1992; Visiting associate in research, National High Magnetic Field Laboratory, 1993-1995; Postdoctoral Fellow, PNNL, 1995-1997; Senior research scientist, PNNL, 1997-2007; Staff scientist and EMSL Capability Steward for Mass Spectrometry, 2007-present.


Ph.D., Chemistry, University of Zagreb, Zagreb, Croatia, 1992
M.S., Theoretical and Physical-Organic Chemistry, University of Zagreb, Zagreb,
Croatia, 1989
B.S., Chemistry, University of Zagreb, Zagreb, Croatia, 1986

Awards, Honors, & Appointments

Nominated for election to the ASMS Board of Directors, 2006 and 2011; PNNL Key Contributor Award, 2002, 2003.
Co-authored 125+ peer-reviewed scientific publications and book chapters; holds 1 patent.

EMSL Publications >View All EMSL Publications